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CNTF either cross-reacts with leptin receptors or directly activates its own receptors present on the hypothalamus, initiating a transduction pathway analogous to that of leptin [72]

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This review aims to outline the role of the IGF/IGF-1R and steroid hormone interplay during normal growth and development, followed by an in-depth look at how these pathways impact metabolism and the potential consequences of this in the development of endocrine-related cancers